Doctors Gates: Innate immunity Vs Adaptive immunity with Brief Video Review

Immune System has 2 arms:

- Innate immune system
- Adaptive immune system

I
Innate immunity (natural or native immunity)
Instant
Immediate
Initial response
Induces adaptive immunity
Integrates with adaptive immunity

Adaptive immune system
Acquired
Await days = no immediate response
Accurate = specific
Autoregulation
Autoimmunity

The Immune Response

Innate immunity is the first line of defense against infections. Innate immunity is specifically against microbes, while adaptive immunity is against any "foreign" substance (including cancer cells, autoantigens, etc.).

Innate immunity is the oldest mechanism of defense. Adaptive immunity (T and B lymphocytes) appeared in jawed vertebrates (sharks) and is superimposed on innate immunity to improve host defense. In a sense, adaptive immunity is an "add-on" to innate immunity.

Innate Recognition of Pathogens